It also prevents insulin resistance [25], LM enhanced mitochondrial biogenesis, and elevated protein levels of hormonal sensitive lipase (HSL), perilipin (PLIN), AMP-activated protein kinase (pAMPK), Phospho acetyl CoA carboxylase (pACC), Acy coenzyme A oxidase (ACO), cytochrome c oxidase subunit 4 (COX4), carnitine palmitoyltransferase 1 (CPT1), and cytochrome C (CYT-C) at the concentration of 25 and 50μM of limonene, which are involved in lipolysis and lipid catabolism via activation of β-adrenergic receptor-3 (β3-AR) and extracellular signal-regulated kinases (ERK) signaling pathway [26]. This evidence concerns the gene LIPE and Insulin resistance.