A study by another group (Itabashi et al., 1997) confirmed the HSV1-APOE-ε4 association in AD, and work on HSV1-infected APOE-transgenic mice has shown that APOE-ε4 animals display a greater viral load, and a greater potential for viral damage (see review Wozniak and Itzhaki, 2010). Here, APOE is linked to Alzheimer disease.