Lirilumab (IPH2102) and monalizumab (IPH2201) are IgG4 monoclonal antibodies (mAbs) currently in clinical development that target KIR2DL1-3 and NKG2A, and antagonize the inhibition of NK cells mediated by HLA-C and HLA-E on tumor cells, respectively (3, 23). This evidence concerns the gene HLA-C and neoplasm.