TNFSF10 and infection: Blocking extrinsic apoptosis by inhibition of Fas/FasL interaction though treatment with a recombinant decoy receptor for FasL or interruption of TRAIL signaling, either by genomic deletion or monoclonal antibody (mAb) blockade (Table 1) during IAV infection can increase the survival rate of mice after IV infection (115, 151, 179, 182–184).