PECAM1 and immune system disorder: Nonetheless, the ability of AnxA12–26 to induce PECAM-1 expression is shown here for the first time, and the molecular basis of this effect will be further investigated regarding the relevance of endothelial PECAM-1 in several pathophysiological conditions, such as cardiovascular and immune diseases (Marelli-Berg et al., 2013; Privratsky and Newman, 2014).