ANXA1 and neoplasm: The direct role of AnxA1 on angiogenesis has not been described, as data regarding AnxA1 on angiogenesis were obtained in in vivo and in vitro tumorigenesis conditions, and data suggest that the tumor microenvironment is determinant to angiogenic actions of AnxA1 (Oh et al., 2004; Yi and Schnitzer, 2009; Anbalagan et al., 2014).