The results of transwell assays showed that overexpression of SNHG5 and inhibition of miR-212-3p could extenuate the reduction of invasion, and migration of si-SGK3 (Fig. 6f), which showed LncRNA SNHG5/miR-212-3p/SGK3 axis regulate the progression of osteosarcoma. Here, SGK3 is linked to osteosarcoma.