Furthermore, TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) fluorescence analysis and Ki67 immunohistochemistry revealed that K145 treatment resulted in both a significant increase in tumor cell apoptosis (Fig. 7f) and a trend towards reduced tumor cell proliferation (Fig. 7g), further consistent with the observed reduction in tumor growth. The gene discussed is MKI67; the disease is neoplasm.