SKP2 and osteosarcoma: Kaplan-Meier analysis and log-rank test revealed that overall survival of patients whose tumors expressed high Skp2 protein levels (n = 15) was significantly worse than for patients whose tumors expressed low Skp2 (n = 35) (p = 0.0128) (Fig. 1E), further demonstrating that Skp2 exerts oncogenic activity in osteosarcoma.