Because of the selection criteria, the sex- and age-matched 43 euclycemic control subjects, 43 patients with impaired fasting glucose (IFG), and 43 patients with manifest T2DM significantly differed by the prevalence of metabolic syndrome as well as frequency distributions of BMI, fasting glucose, HbA1c, C-peptide and insulin (Supplemental Table S3). The gene discussed is INS; the disease is type 2 diabetes mellitus.