The Catalogue Of Somatic Mutations In Cancer (COSMIC)36, the world’s largest and most comprehensive resource for exploring the impact of somatic mutations in human cancer, was used to analyze the expression of POFUT1 in colorectal cancer tissues, the result found that overexpression of POFUT1 occurred in 53.44% (326/610) CRC tissues. The gene discussed is POFUT1; the disease is colorectal carcinoma.