Five variants associated with ADG were located in introns of the following genes: TLL1, CSF2RA, ITFG1, TBC1D16 and BCAS3. TLL1 encodes a member of the tolloid family metalloproteases that have been previously implicated in the cleavage and development of myostatin in humans61. The gene discussed is CSF2RA; the disease is isolated congenital adermatoglyphia.