Altogether, our findings demonstrating that CSLCs from various origins (HMLERshECad, CD133high BTICs, and NT2/D1) express more PHGDH than their cancerous non-stem-like cells counterparts (HMLER, CD133Low GBM) highlight the role of PHGDH in stemness. The gene discussed is PHGDH; the disease is glioblastoma.