PHGDH and cancer: Our findings demonstrating that PHGDH expression is higher in CSLCs (CD133High BTICs, HMLERshECad BCSLCs, and NT2/D1 ECSLCs) compared to various other non-stem-like cancer cells further corroborate these previous reports linking PHGDH with cancer aggressiveness, further supporting the clinical implications for PHGDH in cancer therapy.