Thus, we also analyzed the expression of these proteins in tumor cell supernatant pre-treated HUVECs, and the results showed that low levels of pERK and pAKT were observed in HUVEC-SW1116/CCL19-CM compared with HUVEC-SW1116/Vector-CM, as well as high levels of pERK and pAKT were found in HUVEC-SW620/sh-CCL19-CM compared with HUVEC-SW620/sh-NC-CM (Fig. 4f, g). The gene discussed is CCL19; the disease is neoplasm.