Next, we analysed the changes in FOXM1 expression in GC cells after the ectopic overexpression or silencing of miR-149 and showed that the upregulation of miR-149 could significantly reduce the expression of FOXM1 at the protein level and that silencing of miR-149 could lead to the upregulated expression of FOXM1 at the protein level (Fig. 7a). This evidence concerns the gene FOXM1 and gastric cancer.