BRWD1 and immunodeficiency, common variable, 1: We next performed RNA-Seq on EBV-transformed peripheral blood B cells from two patients (P1 and P2), their mother (PM) who carried the same BRWD1 mutation but was healthy, five healthy controls (C1–C5), and four unrelated common variable immunodeficiency disease (CVID) patients (CVID1-4).