More recently, we further found that GRP75 promotes clathrin-independent endocytosis (CIE) but inhibits clathrin-mediated endocytosis (CME) through the RhoGTPases concurrent activation mechanism25, and this derailed cellular endocytosis phenotype was controlled by the cell-cycle-dependent expression variation of GRP75 in cancer cells26. The gene discussed is HSPA9; the disease is cancer.