PTGS1 and diabetes mellitus: Finally, the hypothesis that the inhibition of COX1-dependent TXA2 biosynthesis is insufficient in this setting is substantiated by data indicating that the use of picotamide, an inhibitor of both TXA2 receptors and TXA2 synthase, might increase survival versus aspirin in patients with diabetes and PAD (RR 0.55, 95% CI 0.31–0.98)125.