TRIM22 and infection: CIITA mRNA expression showed a partially different pattern in that, like TRIM22, it was strongly upregulated in uninfected MDM by stimulation with M1 cytokines; however, unlike TRIM22, its levels returned to baseline in both CTR and M1-MDM 8 days after infection (Fig. 3B, right panel) whereas they were strongly induced by cytokine restimulation in M12 MDM (Fig. 3B, right panel).