An increase in ME1 protein (IHC staining) was observed within normal-appearing villi of the transitional mucosa (P = 0.002) as well as in adenomas (P = 0.026) of ApcMin/+/ME1-Tg when compared to ApcMin/+ mice; by contrast, the crypts of both mouse lines did not differ (Fig. 1D–J). Here, ME1 is linked to adenoma.