Importantly, we found that the distributed recurrence of dynamic connections in the DMN relies on a distinctive genetic profile that mostly depends on LTP genes (such as PRNP), which encodes a membrane glycosylphosphatidylinositol-anchored glycoprotein associated with Creutzfeldt–Jakob disease, fatal familial insomnia, Gerstmann–Straussler disease, Huntington disease-like 1 and kuru, all neurological diseases with signs of sustained aberrant neuronal activity24. Here, PRNP is linked to kuru.