AKT1 and retinal ischemia: Under our experimental setting, retinal ischemia induced a transient dephosphorylation of Akt (Fig. 5D), followed by a significant increase of p-Akt that peaked at 6 h; after 24 h, p-Akt levels in the ischemic retina were comparable to contralateral non-ischemic tissue (Fig. 5D).