In the retina of mice subjected to ischemia, 48 h fasting reduced the phosphorylation of 4EBP1 (Thr37/46) observed after 24 h reperfusion (Figs. 7C and 5B) suggesting that, at this time point, a low mTOR activation state was maintained in the ischemic retina of fasted mice as compared with fed (Fig. 7C). This evidence concerns the gene EIF4EBP1 and ischemia.