Curcumin decreased cognitive impairment as assessed by Morris water maze test, inhibited Aβ generation, and suppressed PI3K, phosphorylated Akt and mammalian target of rapamycin (mTOR—Akt regulating cell growth, proliferation, survival, angiogenesis, as well as autophagy [275]) leading to stimulated autophagy, in APP/PS1 double transgenic mice (an AD mice model) [276]. This evidence concerns the gene AKT1 and Alzheimer disease.