In high-fat diet-induced obese and leptin-deficient ob/ob male C57BL/6J mice, the improved glucose control following curcumin treatment (3% dietary curcumin) was associated with anti-inflammatory effects of curcumin by decreasing macrophage infiltration into adipocytes, and by increasing adiponectin production in white adipocytes, by decreasing ER stress (elevated ER stress in adipocytes and hepatocytes is related to obesity) and perigonadal fat expression of Sirtuin 1 (SIRT1), heat shock proteins (HSP70), HSP90 and Foxo1 and decreasing NF-κB activity in liver [156]. Here, SIRT1 is linked to obesity due to melanocortin 4 receptor deficiency.