They highlighted that OC inhibited the migration and invasion of A375 and A2058 human melanoma cell linesby downregulating the expression of MMP-2/9 [74] by the ability of OC to induce apoptosis in melanoma cells by inhibiting the expression of Bcl-xL and Mcl-1 [74] and reducing the expression of VEGF in melanoma cells, suggesting that the anti-angiogenesis effect of OC on melanoma is associated with VEGF inhibition [74]. This evidence concerns the gene MMP2 and melanoma.