Furthermore, these authors described that OC also inhibits expressionof the cytokines MIP-1α (macrophage inflammatory protein-1α) and IL-6 (interleukin-6), which are mediators of inflammation in rheumatic disease connected with OA in J774 murine macrophages and ATDC5 murine chondrocytes respectively, as well as the secretion of both cytokines in ATDC5 cells [35]. This evidence concerns the gene IL6 and rheumatic disorder.