The higher BMI we observed among consistent exercisers might be due to increased muscle mass, which is expected to affect insulin resistance.19 Insulin functions as a protein anabolic hormone, suppressing degradation of muscle protein and facilitating muscle protein synthesis.20 The degree of change in muscle protein synthesis caused by insulin stimulation is inversely correlated with HOMA-IR, and the protein metabolic cycle is stimulated by physical activity.21 Furthermore, lipids in skeletal muscle cells can have a significant influence on insulin resistance. The gene discussed is INS; the disease is Insulin resistance.