The present study showed that myocardial ischemia–reperfusion resulted in significant inflammatory responses in the group C, but α7nAChR agonist postconditioning, limb remote ischemic postconditioning and combined two interventions significantly reduced myocardial expression of NF-κB in the ischemic area, with decreased serum proinflammatory cytokine levels and infract sizes. Here, CHRNA7 is linked to myocardial ischemia.