To monitor the therapeutic potential of USP14 inhibition in a mitophagy‐deficient background in vivo, we selected animal models of Parkinson's disease (PD), which are associated with mutations in the protein kinase PINK1 and E3 ubiquitin ligase Parkin, both key regulators of mitophagy (Kitada et al, 1998; Shimura et al, 2000; Valente et al, 2004; Silvestri et al, 2005; Narendra et al, 2008, 2010; Ziviani et al, 2010). The gene discussed is USP14; the disease is Parkinson disease.