In vivo, genetic or pharmacological inhibition of USP14 corrected mitochondrial dysfunction and locomotion performance of the PINK1 and Parkin mutant Drosophila model of Parkinson's disease (PD), an age‐related progressive neurodegenerative disorder whose aetiology has been directly correlated with deficient mitochondrial quality control. The gene discussed is PRKN; the disease is Parkinson disease.