While the latter cannot be modelled in undifferentiated stem cells, the fact that patient iPSCs express PKCγ and recapitulate key pathological findings observed in SCA14 cerebellum underscores their potential as relevant tools for disease modeling and drug discovery, in addition to future studies in which SCA14 iPSCs will be differentiated to Purkinje cells. This evidence concerns the gene PRKCG and spinocerebellar ataxia type 14.