SPAG5 and hepatocellular carcinoma: The results showed that the overexpression of ectopic β-catenin inhibited the increases in SCARA5 expression and the cell proliferation ability was also rescued in SPAG5-knockdown Huh7 cells (Fig. 6g-h).We then knocked down β-catenin in SPAG5-overexpressing HCC cells and found that the downregulation of β-catenin could rescue the decreased SCARA5 expression in Hep3B/SPAG5 cells.