APOE and Alzheimer disease: In support of these findings, it has also been shown that the uptake of ApoE-Aβ complexes is reduced in macrophages from human subjects carrying the R47H TREM2 variant [180]; however, whether ApoE isoforms affect TREM2-mediated neuroinflammation response in an isoform-specific manner in the pathogenesis of AD is still unknown.