BACE1 and Alzheimer disease: Importantly, responsive sites for immune-related transcriptional factors which are commonly over-activated during aging and AD, including NF-κB, peroxisome proliferator-activated receptor-γ (PPAR-γ), and STAT-1, have been described in the regulatory promoter region of the genes controlling the expression of APP [46], BACE1 [47–49], and proteins of the γ-secretase complex [50].