Moreover, deletion of progranulin, which has been extensively associated with frontotemporal dementia [135], results in increased TYRO protein tyrosine kinase binding protein (TYROBP) signaling activation and microglial Aβ phagocytosis in the APP/PS1 mouse model, whereas it increases tau pathology in human P301L tau-expressing mice [136]. Here, MAPT is linked to frontotemporal dementia.