Interestingly, SSc patients showing fibrotic changes diffused to upper and lower lobes at lung CT scan, seemed to be characterized by a slightly higher percentage of mixed M1/M2 monocytes/macrophages and characterized as CD14+CD206+CD163+CD80+CD86+ compared to patients with less or no lung fibrosis (0.001 ± 0.008 and 0.0006 ± 0.006, p = 0.044). This evidence concerns the gene CD80 and pulmonary fibrosis.