It is the case, for example, of the presence of the M2 markers CD163 or soluble (s)CD163 that showed to be higher in presence of several organ involvements, like in ILD and pulmonary arterial hypertension (PAH), in SSc and other autoimmune diseases, like polymyositis and dermatomyositis [28, 29]. The gene discussed is CD163; the disease is autoimmune disease.