(E) Representative flow cytometry scatter plot and scatter dot plot with median and interquartile range of the initial gating strategy starting from the circulating CD204+cells percentage (%) in the leucocyte population; (F) Representative flow cytometry panels with quadrant regions and scatter dot plot representation of the of circulating CD204+CD163+CD206+cells in the CD204+cell population; (G) CD204+CD163+CD206+TLR4+cells in the CD204+CD163+CD206+cell subset; (H) CD204+CD163+CD206+TLR4+CD80+CD86+cells and (I) CD14+ and CD14−cells in the CD204+ 163+CD206+TLR4+cell subset of HSs and SSc pts. The gene discussed is MSR1; the disease is systemic sclerosis.