The height of the CPP group, but not the z-score of the height, was associated with IGF-2(3580). The BMI of the CPP group, but not the z-score of the BMI, was associated with IGF-2(3580), IGF1R, and the combinations of [IGF-2(3580) + IGF2R], and [IGF-2(3580) + IGFBP-3]. The gene discussed is IGF2R; the disease is central precocious puberty.