The finding that ATRT may exhibit increased expression of EZH2, and subsequent hypermethylation has led to preclinical testing of EZH2 inhibitors EPZ-6438, 3-deazaneplanocin, and tazemetostat, alone or in combination with other chemotherapies; the data are encouraging, showing some tumor responsiveness to this approach [92,93]. Here, EZH2 is linked to neoplasm.