(2) Mesenchymal stem cells (MSCs) can be transformed into cancer stem cell (CSC)-like cells after specific methylation of two tumor suppressor genes, hypermethylated in cancer 1 (HIC1, NM_001107021) and Ras-association domain family member 1A (RassF1A, NM_001037555.1) [12]. The gene discussed is HIC1; the disease is cancer.