Sartoretto et al. showed increased VASP expression after TAC procedure and in hypertrophic conditions, and this may further strengthen the hypothesis that atherosclerosis, endothelial dysfunction and vessel wall stiffness may generate pressure overload similarly to the TAC model, consistent with our echo results (increased LVOT pressures, wall thickness, E/e’ ratios) presented here [39]. The gene discussed is VASP; the disease is endothelial dysfunction.