EZH2 and breast carcinoma: Moreover, several HDACs (HDAC1, 6 and 8) have been found to be upregulated or overexpressed in breast cancers and to interact with histone-lysine-specific demethylase 1 (LSD1) and EZH2, a component of the polycomb repressor complex, playing an important role in the transcriptional changes involved in breast cancer carcinogenesis.