It may be important, therefore, to be able to advise individual patients on specific vulnerabilities, either in their susceptibility to potential damaging effects of alcohol (e.g., those expressing the defective ALDH2*2 isoform) or with significant risk factors for developing breast cancer, BRCA1 or BRCA2 mutations the impact of which may increase their susceptibility to other potential risk factors. Here, BRCA2 is linked to breast cancer.