More than a dozen ACE inhibitors have been used extensively in the treatment of essential hypertension and heart failure in humans; these include alacepril, benazepril, captopril, cilazapril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, tandolapril, and zofenopril [8,9]. This evidence concerns the gene ACE and hypertensive disorder.