Regarding acquired TMZ resistance, it is known that this phenomenon is mainly modulated by high levels of MGMT protein [152,153,154,155,156,157], somatic inactivation of MMR genes [158], and high expression level of the BER system [159,160]; literature data report that both glioblastoma cell lines and glioblastoma patients with acquired TMZ resistance show a specific miRNAs expression profile [161,162]. This evidence concerns the gene MRC1 and glioblastoma.