Regulators for angiogenesis in cancer, including OSCC, include vascular endothelial growth factors (VEGFs) and fibroblast growth factor-2 [93] COX-2 and PGE2 production have been shown to regulate angiogenesis via vascular endothelial growth factor (VEGF), or they directly modulate endothelial cell proliferation [73]. This evidence concerns the gene VEGFA and cancer.