ROS also contribute to tumour promotion by stimulating expansion of mutated cell clones by temporarily modulating the genes related to proliferation or cell death [62], and regulate the activity of certain transcription factors, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), hypoxia-inducible factor (HIF), and p53 that control cell growth and oncogenesis [67]. Here, NFKB1 is linked to neoplasm.