Here we have linked dysregulation of key signaling pathways (such as the Wnt/β-catenin, the Notch, the NF-κB, the PI3K/Akt/mTOR, and the Hh pathways) and their components to the altered pathological gene and protein expression that contributes to cancer occurrence, progression, growth, invasiveness, metastatic potential, and development of resistance in TNBCs. Here, AKT1 is linked to cancer.