Overexpression of Notch-1 receptor and ligand JAG1 supports the maintenance of breast cancer stem cells (CSCs) [74,75,76] and was crucial for cell survival, apoptotic inhibition, proliferation, adhesion, angiogenesis, metastatic potential, poor prognosis, relapse, and drug resistance in TNBCs [60,73,77]. This evidence concerns the gene JAG1 and breast carcinoma.