AKT1 and hypothyroidism: Two gene sets showed a specific enrichment for hypothyroidism: GO~Rac guanyl-nucleotide exchange factor (GEF) activity (phyperthyroidism = 0.90, phypothyroidism = 8.01 × 10−8; zdifference = −4.89, pdifference = 1.02 × 10−6) and KEGG~JAK/STAT signaling pathway (phyperthyroidism = 0.567; phypothyroidism = 4.41 × 10−9; zdifference = −4.59, pdifference = 4.38 × 10−6).