HLA-C and autoimmune thyroid disease: Comparing the two disorders, 18 enrichments were significant after multiple testing correction in both analyses (Table 3) and these shared mechanisms include many gene sets related to immune function, such as GO~Major Histocompatibility Complex (GO~MHC) class II protein complex (phyperthyroidism = 4.58 × 10−30, phypothyroidism = 2.08 × 10−18) and KEGG~autoimmune thyroid disease (phyperthyroidism = 4.41 × 10−21, phypothyroidism = 6 × 10−22).