IL-8 (CXCL8), the main ligand of CXCR1, is a powerful neutrophil chemotactic factor and its binding to CXCR1 induces activation and migration of neutrophils.58, 59 Taken together, this data, and the recent finding of P. vivax affecting bone marrow60 we hypothesise that the parasite infection could have deep effects on haematopoietic progenitor cells expressing structural related G coupled receptors. This evidence concerns the gene CXCL8 and parasitic infectious disease.