Indeed, there is growing evidences that an appropriate angiogenic state is required for normal pulmonary vascular and alveolar development [10,11], and some studies found lower level of vascular endothelial growth factor (VEGF) in tracheal aspirates and higher level of soluble VEGF receptor (sVEGF-R or sFlt-1) in preterm infants with than without BPD [23]. The gene discussed is VEGFA; the disease is bronchopulmonary dysplasia.