The purpose of this study was to evaluate the diagnostic value of three antigen-specific immune diagnostic tests, namely, the NDO-LID Rapid Test(antibody response), an antigen-specific enzyme linked immunosorbent assay (ELISA)(anti-LID-1, anti-NDO-LID, and anti-ND-O-BSA)(antibody response), and antigen-specific IFN-γ secretion in a whole blood assay (WBA) (stimulated by LID-1, ML89, ML2044 and ML2028)(antigen-specific CMI) for diagnosing leprosy in a hyperendemic area in China. This evidence concerns the gene IFNG and leprosy.