SPP1 and hepatocellular carcinoma: To determine the clinical relevance of the expression of the four genes, we analysed the expression of the proteins encoded by the four genes using clinical specimens from the Human Protein Profiles (http://www.proteinatlas.org).8 SPP1 was strongly positive in HCC and CENPA, and MAGEB6 was weakly positive in HCC, relative to their expression levels in normal liver tissue (Figure 4C).