Levels of mRNA or cytosol IGFBPs are associated with tumour aggressiveness, and the underlying mechanisms are complex and include both IGF‐dependent and IGF‐independent pathways.28 In our results, we observed that IGFBP‐3 mRNA levels were greatly increased in AGS‐EBV cells (Figure 1A). Here, IGFBP3 is linked to neoplasm.