IGFBP3 and bone osteosarcoma: Although the experiment was tested on different type of cancer (bone osteosarcoma), accumulation of nuclear IGFBP‐3 induced apoptosis with proteolysis.33 In our results, inhibition of proliferation did not occur as a result of apoptosis or cell death in AGS‐EBV cells treated with BI836845 (Figure 2B and 4A‐B), but from a delay in entering the S phase of the cell cycle (Figure 5B).