Therefore, we firstly evaluated the phosphorylation of these three proteins and found that tigecycline dramatically inhibited the phosphorylation of mTOR and two downstream effectors 4E‐BP1 and p70S6K in three MM cell lines RPMI‐8226 (Figure 4A), NCI‐H929 (Figure 4B) and U266 (Figure 4C). The gene discussed is EIF4EBP1; the disease is Miyoshi myopathy.