CDH1 and cancer: The extracellular domain of E‐cadherin forms the homologous dimers between neighboring cells and links cell–cell adherens junction(AJ).5 The cytoplasmic tails of ZO proteins attach to actin filaments, thus contributing to the strength and integrity of tight junctions.6 Following a series changes during EMT, epithelial cells lose cell‐cell contacts and apical‐basal polarity while allowing the cells for enhanced ability of invasion and metastasis.7 Upon transition to a mesenchymal state, cancer cells form distant metastasis through the blood or lymphatic system.