Furthermore, we demonstrated that C5aR1 and TLR2 interact in osteoblasts, resulting in upregulation of the immune cell chemoattractant C‐X‐C motif chemokine 10 (CXCL10), which can induce osteoclastic bone resorption.20, 21, 22 These results suggest that complement‐activated osteoblasts are able to modulate the inflammatory milieu during inflammatory bone diseases in concert with osteoclasts and immune cells. Here, TLR2 is linked to bone inflammation disease.