show that tumor‐associated macrophages contribute to abnormal blood vessel formation and angiogenesis, through the utilization of large amounts of glucose and inhibition of mTOR that promotes quiescence of vascular endothelial cells.109 In that study, the hypoxia‐inducible mTOR inhibitor, REDD1 plays an important role in regulating glucose utilization by tumor‐associated macrophages and may be an attractive metabolic target, because REDD1‐targeting resulted in normalization of tumor vessels and reduced metastases. Here, DDIT4 is linked to neoplasm.