MAPK1 and cancer: Meanwhile, mitogen‐activated protein kinase 1 (MAPK1) is involved in a variety of cancer cell processes such as proliferation and migration.18MAPK1 has been proved to mediate EMT as an intracellular signalling molecule, and some signalling molecules can also affect EMT progression through MAPK1 pathway.19 Zhang et al found that miR‐217 regulated tumour growth and apoptosis by targeting the MAPK signalling pathway in colorectal cancer.20 Nevertheless, there are only a few reports about the interaction among CRNDE, miR‐217 and MAPK1 in HCC cells.