Zhu et al reported that lncRNA H19 sponged miR‐675 and repressed prostate cancer metastasis by targeting TGFB1.38 Huan et al revealed that lncRNA CRNDE activated Wnt/β‐catenin pathway through acting as sponge of miR‐136 in breast cancer.39 We did experiments to further explore the underlying mechanisms involved in CRNDE, miR‐217 and MAPK1, and we found that CRNDE could positively regulate the expression of MAPK1, but this increase was reversed by miR‐217 restoration. This evidence concerns the gene H19 and Familial prostate cancer.